4 edition of In Vitro Skin Toxicology found in the catalog.
by Mary Ann Liebert
Written in English
|Contributions||Andre Rougier (Editor), Alan M. Goldberg (Editor), Howard I. Maibach (Editor)|
|The Physical Object|
|Number of Pages||448|
An overview of in vitro toxicology studies covering a range of techniques from cell based assays to indicators of adverse drug interactions, hERG channel inhibition and genotoxicity with mass spectrometer, fluorescence imaging and qRT-PCR endpoints. In Vitro Alternative Test Methods. General Toxicology. Genetic Toxicology. Inhalation Toxicology. Developmental and Reproductive Toxicology (DART) Environmental Safety. The environmental safety of chemicals and man-made materials is a growing concern among the public, regulators and governments worldwide.
Principles and Practice of Skin Toxicology clearly outlines basic concepts, cites historical and modern references and contains a dictionary for easy reference. Covers: Different sections cover skin structure and function, principles and measurement of skin absorption, clinical aspects of dermal toxicity and in vitro alternatives. Alternative Toxicology Testing Services. skin and eye irritation and skin allergenicity but also reduce the use of animals for repeated-dose toxicity, carcinogenicity and reproductive toxicity. We are pro-active in the development and use of in vitro and ex vivo methods partnering researchers and clients in pre-validation and validation.
skin with a less effective barrier, such as in new-born infants, or in cases where the skin is mildly dam-aged or diseased, there are instances where absorption through compromised skin is also important. A tape stripping procedure was investigated using dermatomed pig skin to assess if an in vitro . In vitro inhibitory effects of 1-aminobenzotriazole on drug oxidations catalyzed by human cytochrome P enzymes: A comparison with SKFA and ketoconazole. Drug .
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In Vitro Toxicology details the protocols and methods of in vitro testing, highlighting the usefulness of models, methods and the cost-effectiveness and reproducibility of such current approaches and strategies required to develop an easy, reliable, validated and high throughput system for use in alternative animal models to circumvent in vivo testing are discussed in detail.
In Vitro Skin Toxicology: Irritation, Phototoxicity, Sensitization (Alternative Methods in Toxicology): Medicine & Health Science Books @ This key volume of the Target Organ Toxicology Series provides a fresh and modern approach to the subject of skin toxicology from the perspective of how the skin forms a barrier that protects the body from the external environment and how chemicals and drugs interact with the barrier properties of the skin.
Any defects or perturbations to this barrier may result in damage to the skin or. Book Description. Toxicology has made tremendous strides in the sophistication of the models used to identify and understand the mechanisms of agents that can harm or kill humand and other higher organisms.
Non-animals or in In Vitro Skin Toxicology book models started to gain significant use in the s. Toxicology in Vitro publishes original research papers, reviews and workshop reports focusing on the application and use of in vitro and in silico systems for toxicological evaluations (collectively described as New Approach Methodologies (NAM)).
This includes the utilisation or the development of NAMs for assessing the potential adverse effects of chemicals for human safety assessment. A ready-to-use integrated in vitro skin corrosion and irritation testing strategy using EpiSkin™ model in China Yanfeng Liu, Nan Li, Lizao Chen, Nathalie Alépée, Zhenzi Cai Article In Vitro Toxicology Systems brings together important issues and considerations needed in order to develop a workable, reliable, integrated testing strategy for the replacement of animals in toxicity testing thorough volume includes sections on in vitro models for systemic organ toxicity, neurotoxicity, sensory organs, immunotoxicity and reproductive toxicity and addresses how.
VITRO-SKIN® is an advanced testing substrate that effectively mimics the surface properties of human skin. It has been formulated to have topography, pH, critical surface tension, chemical reactivity and ionic strength that is similar to human skin.
VITRO-SKIN® is currently used by over leading companies worldwide and has been referenced in numerous patents and Continue reading VITRO. Written by authorities in the field, this book provides a “bottom up” approach to studying skin toxicology.
Principles and Practice of Skin Toxicology clearly outlines basic concepts, cites historical and modern references and contains a dictionary for easy reference. The inclusion of global legislation and regulatory aspects on the topic makes this a comprehensive review for every.
She was past-President of both the Dermal and In Vitro Specialty sections of the Society of Toxicology and selected as an Eminent Toxicologist in March by the National Society of Toxicology. Monteiro-Riviere is a Fellow in The Academy of Toxicological Sciences and.
CiteScore: ℹ CiteScore: CiteScore measures the average citations received per peer-reviewed document published in this title. CiteScore values are based on citation counts in a range of four years (e.g.
) to peer-reviewed documents (articles, reviews, conference papers, data papers and book chapters) published in the same four calendar years, divided by the number of. Written by authorities in the field, this book provides a "bottom up" approach to studying skin toxicology.
Principles and Practice of Skin Toxicology clearly outlines basic concepts, cites. First published inthis book describes tissue (cell and organ) culture techniques which could be used at a critical predevelopment stage to screen for drug-inducing toxicity or to analyse the molecular mechanisms of toxicity at a later stage in parallel with investigative studies.
This type of research has important ethical, financial and scientific implications. Purchase In Vitro Biological Systems - 1st Edition.
Print Book & E-Book. ISBNThe book examines other short- and long-term animal toxicity testing methodologies, including dermal, ocular, and reproductive toxicity testing. In addition, mutagenicity and carcinogenicity studies are also discussed in separate chapters.
Section III introduces and discusses in vitro alternatives to animal toxicology tests. Books European Society of Toxicology In Vitro > Books.
Validation of Alternative Methods for Toxicity Testing. ; Editors: Eskes, Chantra, Whelan, Maurice (Eds.) This book provides information on best practices and new thinking regarding the validation of alternative In Vitro Toxicology Systems.
Applied In Vitro Toxicology is a peer-reviewed journal providing the latest research on the development, validation and application of new and innovative in vitro testing methods for predicting adverse effects of drugs, chemicals, and products in the pharmaceutical, chemical, or personal care Journal addresses in depth the issues facing these industries, by including discussions.
Reflecting the embryonic state of the field, the first edition of Dermatoxicology, published innumbered pages.
Now the foundational reference in dermal toxicology, this seventh edition consists of 1, pages and defines what was once a largely intuitive field but has evolved into an established science of metrics and mechanisms/5(3).
9 hours ago New York, Aug. 06, (GLOBE NEWSWIRE) -- According to the current analysis of Reports and Data, the Global In-Vitro Toxicology/Toxicity Testing market was valued at. IN VITRO TOXICOLOGY Blood/Plasma Compatibility • Acute toxicity using 3T3 NRU test (OECD ) • Skin Corrosion (OECD ) MatTek EpiDerm™ model • • MatTek EpiSkin™ model • • Membrane Barrier Test Method for Skin Corrosion (CorrositexTM; OECD ) • Skin Irritation (OECD ).
The book also tackles difficult areas of toxicology such as carcinogenicity and nanotoxicology, with additional chapters dedicated to kinetics, metabolism, and in vitro in vivo extrapolation.
The book also addresses biological processes such as stress response pathways and mechanistic biomarkers and how these can be uncovered and measured using.Abstract.
This book contains 18 chapters. Some of the titles are: Genetic toxicology; In vitro dermal irritancy tests; An in vitro assessment of ovarian function: a potential tool for investigating mechanisms of toxicity in the ovary; In vitro immunotoxicology; and Postimplantation embryo culture and its applications to problems in teratology.The U.S.
Tox21 collaborative program represents a paradigm shift in toxicity testing of chemical compounds from traditional in vivo tests to less expensive and higher throughput in vitro methods to prioritize compounds for further study, identify mechanisms of action, and ultimately develop predictive models for adverse health effects in humans.
The NIH Chemical Genomics Center (NCGC) is an.